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W Gillies McKenna Selected Research

Radiotherapy

1/2019Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma.
1/2017PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
1/2017Depletion of signal recognition particle 72kDa increases radiosensitivity.
2/2015Drug radiotherapy combinations: review of previous failures and reasons for future optimism.
5/2013A treatment planning comparison of four target volume contouring guidelines for locally advanced pancreatic cancer radiotherapy.
12/2012The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.
9/2012The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
4/2012Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.
3/2012NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity.
1/2012Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.
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W Gillies McKenna Research Topics

Disease

32Neoplasms (Cancer)
01/2021 - 05/2002
8Hypoxia (Hypoxemia)
01/2021 - 01/2012
8Pancreatic Neoplasms (Pancreatic Cancer)
01/2016 - 08/2004
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 05/2002
4Adenocarcinoma
01/2017 - 05/2013
3Neoplasm Metastasis (Metastasis)
11/2016 - 06/2008
3Head and Neck Neoplasms (Head and Neck Cancer)
11/2004 - 05/2002
2Carcinogenesis
11/2012 - 04/2007
1Chromosome Aberrations (Chromosome Abnormalities)
01/2018
1Disease Progression
11/2016
1Lymphatic Metastasis
01/2016
1Ichthyin-Related Autosomal Recessive Congenital Ichthyosis
01/2016
1Squamous Cell Carcinoma of Head and Neck
02/2015
1Hypopharyngeal Neoplasms
03/2012
1Urinary Bladder Neoplasms (Bladder Cancer)
03/2012
1Necrosis
03/2012
1Breast Neoplasms (Breast Cancer)
01/2012
1Acute Cholecystitis
06/2008
1Colorectal Neoplasms (Colorectal Cancer)
04/2007
1Insulin Resistance
09/2005
1Carcinoma (Carcinomatosis)
09/2005
1Lung Neoplasms (Lung Cancer)
08/2004
1Brain Neoplasms (Brain Tumor)
11/2003
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2003
1Glioma (Gliomas)
11/2003
1Hyperglycemia
01/2003

Drug/Important Bio-Agent (IBA)

6Farnesyltranstransferase (Farnesyltransferase)IBA
04/2007 - 05/2002
5ErbB Receptors (EGF Receptor)IBA
08/2009 - 11/2003
4Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
03/2012 - 09/2005
4Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
07/2008 - 12/2003
3Nelfinavir (Viracept)FDA Link
01/2016 - 06/2008
3HIV Protease InhibitorsIBA
01/2016 - 09/2005
3Phosphotransferases (Kinase)IBA
09/2012 - 11/2003
3Small Interfering RNA (siRNA)IBA
04/2010 - 09/2005
3L 778,123IBA
11/2004 - 05/2002
2DNA (Deoxyribonucleic Acid)IBA
01/2018 - 09/2012
2Eosine Yellowish-(YS) (Eosin)IBA
11/2016 - 07/2016
2GemcitabineFDA Link
01/2016 - 09/2012
2MTOR InhibitorsIBA
12/2012 - 03/2012
2Proteins (Proteins, Gene)FDA Link
03/2012 - 09/2005
2dactolisibIBA
03/2012 - 01/2012
2Oncogene Proteins (Oncogene Protein)IBA
07/2008 - 08/2004
2Dimethylallyltranstransferase (Dimethylallyltransferase)IBA
09/2005 - 08/2005
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
08/2004 - 11/2003
2Gefitinib (Iressa)FDA Link
11/2003 - 03/2002
22- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
07/2003 - 03/2002
1RNA (Ribonucleic Acid)IBA
01/2021
1Messenger RNA (mRNA)IBA
01/2021
1Antimalarials (Antimalarial Agents)IBA
01/2021
1Atovaquone (Mepron)FDA Link
01/2021
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2019
1NVP-BKM120IBA
01/2019
1RO 3306IBA
01/2018
1Interferon LambdaIBA
01/2018
1EnzymesIBA
01/2018
1ImmunosorbentsIBA
01/2018
1CDC2 Protein Kinase (Protein p34cdc2)IBA
01/2018
1fluoromisonidazoleIBA
09/2017
1imidazole mustard (BIC)IBA
09/2017
1Immune Checkpoint InhibitorsIBA
01/2017
1Carbonic Anhydrase IXIBA
11/2016
1LigandsIBA
07/2016
1Radiation-Sensitizing AgentsIBA
01/2016
1Thiamine (Aneurin)FDA Link
03/2015
1PyrithiamineIBA
03/2015
1Cetuximab (Erbitux)FDA Link
02/2015
1Monoclonal AntibodiesIBA
02/2015
1CytokinesIBA
12/2012
1Hypoxia-Inducible Factor 1IBA
12/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2012
1Rad30 proteinIBA
11/2012
1DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
11/2012
13- amino- 6- (4- (methylsulfonyl)phenyl)- N- phenylpyrazine- 2- carboxamideIBA
09/2012
1Mechanistic Target of Rapamycin Complex 2IBA
03/2012
18- (6- methoxypyridin- 3- yl)- 3- methyl- 1- (4- piperazin- 1- yl- 3- trifluoromethylphenyl)- 1,3- dihydroimidazo(4,5- c)quinolin- 2- oneIBA
03/2012
1Mechanistic Target of Rapamycin Complex 1IBA
03/2012
1TOR Serine-Threonine KinasesIBA
03/2012
12- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
01/2012
1Angiogenesis InhibitorsIBA
01/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2012
1DNA Polymerase thetaIBA
04/2010
1PI103IBA
07/2008
1Protease Inhibitors (Protease Inhibitor)IBA
06/2008
1Transaminases (Aminotransferases)IBA
06/2008
1Protein Isoforms (Isoforms)IBA
09/2005
1geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA
08/2004
1Cyclin-Dependent Kinases (cdk Proteins)IBA
11/2003
14- ((3- bromophenyl)amino)- 6,7- dimethoxyquinazolineIBA
11/2003
1Epidermal Growth Factor (EGF)IBA
11/2003
13-Iodobenzylguanidine (Iobenguane)IBA
01/2003
1Glucose (Dextrose)FDA LinkGeneric
01/2003
1benzylguanidineIBA
01/2003

Therapy/Procedure

18Radiotherapy
01/2019 - 05/2002
8Therapeutics
01/2018 - 07/2002
3Adjuvant Chemotherapy
11/2016 - 01/2016
3Drug Therapy (Chemotherapy)
02/2014 - 09/2012
2Chemoradiotherapy
01/2016 - 06/2008
1Pancreatectomy
11/2016
1Stents
06/2008